The Herat province, a desolate area dotted with mud brick dwellings, was the site of the 6.3-magnitude earthquake that occurred on Saturday morning.
Villagers are reportedly still searching for the missing, who number more than 500, with shovels and only their bare hands.
Due to traffic jams and broken communication lines, aid only slowly began to arrive on Monday.
The UN Office for the Coordination of Humanitarian Affairs (OCHA) estimates that "100% of dwellings are estimated to have been entirely destroyed" in Zindajan, a rural area some 40 kilometers (25 miles) outside of Herat city.
Images from the communities show whole houses crushed to rubble, showing how frail they were to resist such an earthquake.
Initial estimates of the death toll or the number of people still missing proved difficult for the Taliban government and aid organizations. It's improbable that authorities have population statistics for such far-flung settlements.
The region is also home to villages that were uprooted due to war and drought, making it challenging for the local government to determine the precise number of residents.
Over 1,600 injured people are currently being treated in under-resourced hospitals. Numerous of them were delivered to the Herat Regional Hospital, where MSF teams have been present since Saturday.
Prue Coakley, the interim national representative for MSF in Afghanistan, notes that it is fortunate that the majority of patients entering are not urgent situations. But many of them don't have someplace to go back to, so many of them are staying at the hospital while officials try to find them other places to stay.
She also mentioned that a team with expertise in pediatric patients had been dispatched to the Herat hospital. Women and children make up the bulk of the earthquake survivors receiving medical attention, according to the UN, and many of the deceased, according to physicians who spoke to the BBC.
According to the Taliban administration, earthquake victims urgently want food, water for drinking, medicine, clothing, and tents for shelter. Help has been sent by a number of humanitarian organizations, including the Afghan Red Cross Society, MSF, the World Food Programme, and Unicef. However, the agencies claim that the poor nation needs greater assistance.
Since the Taliban took control of the country in 2021 and the direct help to the government was terminated, Afghanistan has been suffering from an economic disaster.
Since Saturday's earthquake, few nations have made financial commitments. According to Chinese media, the Red Cross Society of China has granted emergency cash assistance of $200,000 (£164,220).
Pakistan, which borders Afghanistan, has declared that it is in touch with Afghan authorities and will "provide all available support to the recovery effort."
Due to its proximity to the meeting point of the Indian and Eurasian tectonic plates, Afghanistan experiences earthquakes often, particularly in the Hindu Kush mountain region.
More than 1,000 people were killed and tens of thousands of people were left homeless when a 5.9 magnitude earthquake struck the province of Paktika in June of last year.