According to a local radio station, 40 individuals have died and numerous others are still missing.
Floods hindered rescue attempts, forcing people to use their bare hands to dig bodies out of the rubble.
On Sunday, the Mefou River overflowed its banks due to heavy rain, flooding several neighborhoods.
The poor neighborhood of Mbankolo was most hit, with several slope-built homes collapsing and uprooted banana plants.
Local neighbor Ymele Guy told the BBC that the landslide claimed the life of his child.
He added, "I saw the calamity and in the space of a second, my children and I were being submerged, just as I was telling my wife that things were horrible.
"I rescued my wife and three or more of my kids. The fourth was carried away by the rain, which also "snatched that youngster away."
According to Jouego Cathérine, her pregnant sister is still under the rubble.
"I still haven't located my sister. In April, she got married. All seven of them passed away here along with her in-laws. The final two bodies, my sister and a small child, are still missing after five bodies have already been found.
Because of the unstable soil, residents should leave, Interior Minister Paul Atanga Nji told the iGONG.
He stated, "We are organizing rescue attempts, mattresses, blankets, and everything that," and added that one of those who had been saved was a three-month-old baby.
Nearly a year has passed since Yaoundé saw a landslide that killed at least 14 people.
Authorities in neighboring Nigeria issued flood warnings to citizens on Saturday after Cameroon started releasing water from its Lagdo Dam. Nine states were affected.
According to the National Emergency Management Agency (Nema) of Nigeria, this is anticipated to continue through the end of this month. It also stated that the Cameroon dam was anticipated to release water till the end of October.
According to Cameroon, the country's north has seen severe rainfall, necessitating the discharge of water.
Officials said that the release would be kept to a minimum.
In Nigeria last year, flooding and fatalities were brought on by the dam's water discharge, particularly in the Cameroonian border state of Benue.